Teacher's Page for the Genetic Diseases WebQuestA WebQuest for 7th Grade Science Designed by Pamela Aban sweet15pea@yahoo.com
IntroductionThis webquest lesson was developed as part of the course CLIS 741 Educational Services in Libraries at the University of South Carolina for the Master of Library and Information Science program.This webquest is designed as a medical conference for the student "medical interns" to research various genetic diseases, share their information with their colleagues, and collaborate with their colleagues on ideas on ways to make life easier for their patients and for areas of further research to find a cure. Here is a MS PowerPoint Presentation to introduce the webquest and the research process to the students before beginning this project: PowerPoint Introduction. Back to Top LearnersThis lesson is anchored in seventh grade gifted science class.A basic understanding of genetics and heredity prior to the webquest would be helpful, especially in understanding some of the terminology. Glossaries are provided, but they may not be comprehensive. The concepts of chromosomes and mutations would be beneficial. Basic computer skills are also necessary. A familiarity with creating MS PowerPoint slides would be helpful, but not necessary. Allow for more time if the students are not familiar with PowerPoint. Back to Top Curriculum StandardsScience Standards Addressed: Columbia County MCREL Science Standards Standard 6. E. Relates abnormal patterns of genetic inheritances to genetic disorders and diseases Standard 13: Understands the nature of scientific inquiry and knowledge Standard 13. C. Understands that questioning, response to criticism, and open communication are integral to the process of science Standard 13. D. Knows that the scientific method is an investigation that involves systematic observations, carefully collected, relevant evidence, logical reasoning, and some imagination in developing hypotheses and explanation Standard 13. G. Uses appropriate tools (including computer hardware and software) and techniques to gather, analyze, and interpret scientific data Standard 13. H. Establishes relationships based on evidence and logical argument (e.g., proves causes for effects) Standard 13. I. Understands the nature of scientific explanations (e.g., emphasis on evidence; use of logically consistent arguments; use of scientific principles, models, and theories; acceptance or displacement based on new scientific evidence) Standard 14. A. Knows that people of all backgrounds and with diverse interests, talents, qualities, and motivations engage in fields of science and engineering; some of these people work in teams, and others work alone, but all communicate extensively with others Columbia County Values Correlation 15. Compassion 27. Knowledge Information Literacy Standards Standard 1: The student who is information literate accesses information efficiently and effectively. Indicator 1: Recognizes the need for informationStandard 2: The student who is information literate evaluates information critically and competently. Indicator 4: Selects information appropriate to the problem or question at hand.Standard 3: The student who is information literate uses information accurately and creatively. Indicator 2: Integrates new information into one’s own knowledge.Standard 5: The student who is an independent learner is information literate and appreciates literature and other creative expressions of information. Indicator 3: Develops creative products in a variety of formats.Standard 7: The student who contributes positively to the learning community and to society is information literate and recognizes the importance of information to a democratic society. Indicator 2: Respects the principle of equitable access to information.Standard 8: The student who contributes positively to the learning community and to society is information literate and practices ethical behavior in regard to information and information technology. Indicator 2: Respects intellectual property rights.Standard 9: The student who contributes positively to the learning community and to society is information literate and participates effectively in groups to pursue and generate information. Indicator 1: Shares knowledge and information with others. ISTE National Educational Technology Standards 2: Social, ethical, and human issues ii. Students practice responsible use of technology systems, information, and software.3. Technology productivity tools i. Students use technology tools to enhance learning, increase productivity, and promote creativity5. Technology research tools i. Students use technology to locate, evaluate, and collect information from a variety of sources6. Technology problem-solving and decision-making tools i. Students use technology resources for solving problems and making informed decisions Back to Top ProcessEach student will complete the following process:1. First the student "intern" will be given a case study prepared by you, the Chief Resident, on a patient who is ill in your clinic. Each intern will receive a different case study. If you have more than 18 students, you may want to give out duplicate diseases, maybe with different patient names. These case studies were created using the symptoms listed on the Your Genes Your Health website. The patient names are purely fictional. Case Studies: pdf of all case studies [It may be easier to pre-assign who has each disease, then create a list to check off as they confirm their diagnosis. You may want to print out this code sheet pdf to keep track.] 2. Each intern will read and review their case study carefully for clues based the patient description and symptoms. Based on the information provided on the case study, they will visit the following site in order to explore the various genetic diseases and their symptoms. This will help them to make your diagnosis. Make Your Diagnosis [Headphones may be needed for each student to listen to video clips.] Glossary1 Glossary
2 for clarification of terms
6. In order for them to conduct their research, they have been provided with the following Internet resources: Sites with Various Genetic Disease Information: Genetics Home Reference: The U.S. National Library of Medicine provides a service that includes this guide to understanding genetic conditions. Includes information on what is new, a handbook, glossary, resources, a search box, and the browse option for exploring more information on each disease. Genetic Information and Patient Services: a non-profit organization providing information on the Internet about genetic disorders and birth defects. Includes definitions of disorders, resources, and a glossary. Genetic Disorders: The National Institutes of Health, National Human Genome Research Institute provides an overview of genetic diseases and information on some specific genetic disorders. Blazing the Genetic Trail, Howard Hughes Medical Institute: Information on why there are so many errors in our DNA, how genetic disorders are inherited, and how to conquer a genetic disease. Genetic and Rare Conditions Site, U of Kansas Medical Center: Includes advocacy and support groups, information on genetic conditions and birth defects, and national and international organizations. Sites for Specific Genetic Diseases: 7. Each intern will also need to visit your school or local public library and use (1) print resource to obtain additional information on the disease. The print resource may be an encyclopedia, a book, or a magazine. 8. Remind them to always cite their sources that were used for their research and presentation. There is a space at the bottom of the scientific journal pdf for recording citations. If they need help, following one of these links: OSLIS Citation Maker or NoodleBib 5. Citation Examples: Book Citation: Author's Last Name, First Name Middle Name. Title of Book. City of Publication: Publisher's Name, Year of Publication. Magazine Citation: Last Name, First Name Middle Name. "Title of Article." Name of Magazine. Date of Publication: Page Numbers of Article. Webpage Citation: Last Name, First Name Middle Name. "Specific Page or Article Title." Title of Entire Web Site. Date Web Page Was Last Revised. Sponsoring Organization. Date You Read It <URL>. 9. Once they have investigated the genetic disease, they will create a MS PowerPoint presentation (guidelines here pdf) to present to their fellow medical interns at the Genetic Disease Conference. PowerPoint Tips and Guidelines pdf are here for a printout. This will be an opportunity for them to give an oral and multimedia presentation using graphics on the results of their research. Professionals often meet at conferences in order to present and share ideas and discoveries with their colleagues. [You may want to give them this blank storyboard or title storyboard for them to help organize their slides. Also, if students complete their PowerPoint earlier than other students, there are genetic crossword puzzles, cryptograms, and other games at the Gene School '99 website.] 10. As part of the conference and following the genetic disease presentations, they will participate in a brainstorming pdf session with the other young, bright, and innovative medical interns on ideas that warrant further investigative research into possible cures or treatments for these various genetic diseases. You may choose to use this Conference Brainstorming PowerPoint to guide the session. [The brainstorming session is a class discussion after the presentations. When the conference and presentations begin, you might let them wear lab coats and stethoscopes as props while presenting.] 11. Select an intern or have the Chief Resident record the ideas. Also, as Part II of this session, record questions that they would like to ask a genetic counselor or genetic researcher in order to further their understanding of the diseases. [If possible, ask a researcher or counselor to visit the class after the "brainstorming sessions" to answer their questions.] 12. For the disease that they diagnosed and investigated, what would they recommend to the family of the patient based on what they have learned? After consulting with their fellow colleagues if needed,
Brainstorming Guide pdf This lesson is designed to include:
The teacher will need to be familiar with computers and MS PowerPoint. Variations You might consider inviting parents and others to attend the
presentations at the conference. This will give the students an
opportunity to present to the community. You might consider serving
coffee, sodas, and/or doughnuts for the conference attendees. Also, you
might invite a genetic researcher or genetic counselor to the class
after the conference to answer students' questions. Back to Top Resources Needed:
Arnold, Caroline. Genetics: From Mendel to Gene Splicing. New York: Franklin Watts, 1986. Bornstein, Sandy. What Makes You What You Are: A First Look at Genetics. Englewood Cliffs, NJ: Julian Messner, 1989. Brown, Fern G. Hereditary Diseases. New York: Franklin Watts, 1987. Edelson, Edward. Birth Defects. New York: Chelsea House Publishers, 1992. Facklam, Margery and Howard Facklam. From Cell to Clone. San Diego: Harcourt Brace Javanovich, 1979. Graham, Ian. Genetics: The Study of Heredity. Milwaukee, WI: Gareth Stevens Publishing, 2002. Gutnick, Martin J. Genetics: Projects for Young People. New York: Franklin Watts, 1985. Holmes, Fiona. Tomorrow's World Medicine. London: British Broadcasting Corp., 1985. Hyde, Margaret O. and Lawrence E. Hyde. Cloning and the New Genetics. Hillside, NJ: Enslow Publishers,Inc., 1984. Lampton, Christopher. DNA and the Creation of New Life. New York: Arco Publishing, Inc., 1983. Marshall, Diana, ed. The Revolution in Genetics: Understanding Global Issues. North Mankato, MN: Smart Apple Media, 2003. Silverstein, Alvin and Virginia Silverstein. The Genetics Explosion. New York: Macmillan Publishing Company, 1980. Swisher, Clarice. Genetic Engineering. San Diego, CA: Lucent Books, Inc., 1996.
Baker, Dan, Mark Anunson, and Josh Cracraft. "Gene School '99." 1999. Oracle Education Foundation ThinkQuest. 3 October 2004. Available URL: http://library.thinkquest.org/28599/links_gene_therapy.htm "Blazing the Genetic Trail." Spring 2002. Howard Hughes Medical Institute. 4 October 2004. Available URL: http://www.hhmi.org/genetictrail/ Devore, David. "Genetic Screening and Ethics." 1992. Access Excellence at the National Health Museum. Woodrow Wilson Biology Institute. 4 October 2004. Available URL: http://www.accessexcellence.org/AE/AEPC/WWC/1992/gen_screen1.html Dolan DNA Learning Center. "Your Genes, Your Health: A Multimedia Guide to Genetic Disorders." 2002. Cold Spring Harbor Laboratory. Internet. 1 October 2004. Available URL: www.yourgenesyourhealth.org Collins, Debra. "Genetic and Rare Conditions Site." 2004. Medical Genetics, University of Kansas Medical Center. 4 October 2004. Available URL: http://www.kumc.edu/gec/support/ Genetic Information and Patient Services, Inc."The GAPS Index to Infomration on the Internet about Genetic Disorders and Birth Defects." Arizona State Public Information Network. 13 October 2004. Available URL: http://aspin.asu.edu/geneinfo/index.html GeneTests. "Glossary." 2004. University of Washington, Seattle, WA. 4 October 2004. Available URL: http://www.geneclinics.org/servlet/access?qry=ALLTERMS&db=genestar&fcn=term>report2=true&id= 8888891&key=2Fom71itycp1e "Genetics Home Reference: Your Guide to Understanding Genetic Conditions." 8 October 2004. U.S. National Library of Medicine. Internet. 4 October 2004. Available URL: http://ghr.nlm.nih.gov/ "How Cells Work." 2004. HowStuffWorks, Inc. 4 October 2004. Available URL: http://science.howstuffworks.com/cell.htm National Human Genome Research Institute. "All About the Human Genome Project." August 2004. The National Institutes of Health. 4 October 2004. Available URL: http://www.genome.gov/10001772 National Human Genome Research Institute. "Specific Genetic Disorders." October 2004. The National Institutes of Health. 4 October 2004. Available URL: http://www.genome.gov/10001204 National Human Genome Research Institute. "Talking Glossary of Genetic Terms." 2004. The National Institutes of Health. 4 October 2004. Available URL: http://www.genome.gov/10002096 "NoodleBib5." 2004. Noodle Tools, Inc. 4 October 2004. Available URL: http://www.noodletools.com/noodlebib/citeone.php "OSLIS Citation Maker." 28 May 2003. Oregon School Library Information System. 4 October 2004. Available URL: http://www.oslis.k12.or.us/citeintro/ctimeout.php U.S. National Library of Medicine. "Genetics Home Reference: Your Guide to Understanding Genetic Conditions." 24 September 2004. Internet. 2 October 2004. Available URL: http://ghr.nlm.nih.gov/ Specific Diseases National Websites "Alzheimer's Association." 2004. Alzheimer's Association. 4 October 2004. Available URL: http://www.alz.org/ "Bleeding Disorders Info Center." 25 September 2004. National Hemophilia Foundation. 15 October 2004. Available URL: http://www.hemophilia.org/home.htm "Breaking the Sickle Cycle." 14 March 2004. Sickle Cell Disease Association of America, Inc. 15 October 2004. Available URL: http://www.sicklecelldisease.org/default.htm "Cooley's Anemia Foundation: Leading the Fight Against Thalassemia." 2001. Cooley's Anemia Foundation. 4 October 2004. Available URL: http://www.thalassemia.org/ "Cystic Fibrosis Foundation Home Page." Cystic Fibrosis Foundation. 4 October 2004. Available URL: http://www.cff.org/home/ "Fraxa Home Page." 2004. The Fragile X Research Foundation. 15 October 2004. Available URL: http://www.fraxa.org/ "HDSA Home Page." Huntington's Disease Society of America. 15 October 2004. Available URL: http://www.hdsa.org/ "The National Down Syndrome Society Web Site." 2004. National Down Syndrome Society. 4 October 2004. Available URL: http://www.ndss.org/ "National PKU News: News and Information about Phenylketonuria." October 2004. The National PKU News. Available URL: http://www.pkunews.org/ "Neurofibromatosis Home Page." 2004. The National Neurofibromatosis Foundation. 15 October 2004. Available URL: http://www.nf.org/ "NMF Home Page." 2004. The National Marfan Foundation. 15 October 2004. Available URL: http://www.marfan.org/nmf/index.jsp "Parent Project: Muscular Dystrophy: Leading the Duchenne Muscular Dystrophy Community." 12 October 2004. Parent Project Muscular Dystrophy. 15 October 2004. Available URL: http://www.parentprojectmd.org/news/latest/index.html "PKD Foundation: For Research in Polycyctic Kidney Disease." PKD Foundation. 15 October 2004. Available URL: http://www.pkdcure.org/home.htm "Prevention Through Genetic Testing." 10 October 2004. American Hemochromatosis Society. 15 October 2004. Available URL: http://www.americanhs.org/ "Welcome to the National Tay-Sachs & Allied Diseases Association, Inc. Web Site." NTSAD. 15 October 2004. Available URL: http://www.ntsad.org/
Optional Materials:
Back to Top EvaluationThese are the rubrics for which their work will be evaluated. Their grade will consist of three individual test grades: one for the research, one for the PowerPoint, and one for the presentation. Research Rubric pdf PowerPoint Rubric pdf Presentation Rubric pdf This rubric contains an abbreviated version of the above three rubrics condensed to one page for easier grading. pdf Back to Top ConclusionWhat an amazing group of medical interns you have! They have successfully diagnosed, researched, and creatively presented their findings to their colleagues. They have learned a great amount of information about other genetic diseases, as well as using research skills, and collaborating and sharing of information. They have developed a sense of compassion for their patients by learning about what life is like for each patient and the difficulties they must endure. This will help them become an informed patient, family member, or perhaps, one day, a future physician. They have done a wonderful job of developing ideas for future research investigations into these diseases. Maybe one of them will find a cure for one of these genetic diseases one day! Back to Top Credits & ReferencesI would like to say a special thank you to Mrs. Linda Strother, 7th grade Gifted Science teacher at Lakeside Middle School in Evans, Georgia, for all of her help and suggestions while collaborating on this project. I would also like to thank my professor at the University of South Carolina, Mrs. Amanda LeBlanc for her guidance, and to Mrs. Kim Isiminger, School Media Specialist at Lakeside Middle School, for all of her help.Books Arnold, Caroline. Genetics: From Mendel to Gene Splicing. New York: Franklin Watts, 1986. Bornstein, Sandy. What Makes You What You Are: A First Look at Genetics. Englewood Cliffs, NJ: Julian Messner, 1989. Brown, Fern G. Hereditary Diseases. New York: Franklin Watts, 1987. Edelson, Edward. Birth Defects. New York: Chelsea House Publishers, 1992. Facklam, Margery and Howard Facklam. From Cell to Clone. San Diego: Harcourt Brace Javanovich, 1979. Graham, Ian. Genetics: The Study of Heredity. Milwaukee, WI: Gareth Stevens Publishing, 2002. Gutnick, Martin J. Genetics: Projects for Young People. New York: Franklin Watts, 1985. Holmes, Fiona. Tomorrow's World Medicine. London: British Broadcasting Corp., 1985. Hyde, Margaret O. and Lawrence E. Hyde. Cloning and the New Genetics. Hillside, NJ: Enslow Publishers,Inc., 1984. Lampton, Christopher. DNA and the Creation of New Life. New York: Arco Publishing, Inc., 1983. Marshall, Diana, ed. The Revolution in Genetics: Understanding Global Issues. North Mankato, MN: Smart Apple Media, 2003. Silverstein, Alvin and Virginia Silverstein. The Genetics Explosion. New York: Macmillan Publishing Company, 1980. Swisher, Clarice. Genetic Engineering. San Diego, CA: Lucent Books, Inc., 1996. Websites Baker, Dan, Mark Anunson, and Josh Cracraft. "Gene School '99." 1999. Oracle Education Foundation ThinkQuest. 3 October 2004. Available URL: http://library.thinkquest.org/28599/links_gene_therapy.htm "Blazing the Genetic Trail." Spring 2002. Howard Hughes Medical Institute. 4 October 2004. Available URL: http://www.hhmi.org/genetictrail/ Devore, David. "Genetic Screening and Ethics." 1992. Access Excellence at the National Health Museum. Woodrow Wilson Biology Institute. 4 October 2004. Available URL: http://www.accessexcellence.org/AE/AEPC/WWC/1992/gen_screen1.html Dolan DNA Learning Center. "Your Genes, Your Health: A Multimedia Guide to Genetic Disorders." 2002. Cold Spring Harbor Laboratory. Internet. 1 October 2004. Available URL: www.yourgenesyourhealth.org Collins, Debra. "Genetic and Rare Conditions Site." 2004. Medical Genetics, University of Kansas Medical Center. 4 October 2004. Available URL: http://www.kumc.edu/gec/support/ Genetic Information and Patient Services, Inc."The GAPS Index to Infomration on the Internet about Genetic Disorders and Birth Defects." Arizona State Public Information Network. 13 October 2004. Available URL: http://aspin.asu.edu/geneinfo/index.html GeneTests. "Glossary." 2004. University of Washington, Seattle, WA. 4 October 2004. Available URL: http://www.geneclinics.org/servlet/access?qry=ALLTERMS&db=genestar&fcn=term>report2=true&id= 8888891&key=2Fom71itycp1e "Genetics Home Reference: Your Guide to Understanding Genetic Conditions." 8 October 2004. U.S. National Library of Medicine. Internet. 4 October 2004. Available URL: http://ghr.nlm.nih.gov/ "How Cells Work." 2004. HowStuffWorks, Inc. 4 October 2004. Available URL: http://science.howstuffworks.com/cell.htm National Human Genome Research Institute. "All About the Human Genome Project." August 2004. The National Institutes of Health. 4 October 2004. Available URL: http://www.genome.gov/10001772 National Human Genome Research Institute. "Specific Genetic Disorders." October 2004. The National Institutes of Health. 4 October 2004. Available URL: http://www.genome.gov/10001204 National Human Genome Research Institute. "Talking Glossary of Genetic Terms." 2004. The National Institutes of Health. 4 October 2004. Available URL: http://www.genome.gov/10002096 "NoodleBib5." 2004. Noodle Tools, Inc. 4 October 2004. Available URL: http://www.noodletools.com/noodlebib/citeone.php "OSLIS Citation Maker." 28 May 2003. Oregon School Library Information System. 4 October 2004. Available URL: http://www.oslis.k12.or.us/citeintro/ctimeout.php U.S. National Library of Medicine. "Genetics Home Reference: Your Guide to Understanding Genetic Conditions." 24 September 2004. Internet. 2 October 2004. Available URL: http://ghr.nlm.nih.gov/ Specific Diseases National Websites "Alzheimer's Association." 2004. Alzheimer's Association. 4 October 2004. Available URL: http://www.alz.org/ "Bleeding Disorders Info Center." 25 September 2004. National Hemophilia Foundation. 15 October 2004. Available URL: http://www.hemophilia.org/home.htm "Breaking the Sickle Cycle." 14 March 2004. Sickle Cell Disease Association of America, Inc. 15 October 2004. Available URL: http://www.sicklecelldisease.org/default.htm "Cooley's Anemia Foundation: Leading the Fight Against Thalassemia." 2001. Cooley's Anemia Foundation. 4 October 2004. Available URL: http://www.thalassemia.org/ "Cystic Fibrosis Foundation Home Page." Cystic Fibrosis Foundation. 4 October 2004. Available URL: http://www.cff.org/home/ "Fraxa Home Page." 2004. The Fragile X Research Foundation. 15 October 2004. Available URL: http://www.fraxa.org/ "HDSA Home Page." Huntington's Disease Society of America. 15 October 2004. Available URL: http://www.hdsa.org/ "The National Down Syndrome Society Web Site." 2004. National Down Syndrome Society. 4 October 2004. Available URL: http://www.ndss.org/ "National PKU News: News and Information about Phenylketonuria." October 2004. The National PKU News. Available URL: http://www.pkunews.org/ "Neurofibromatosis Home Page." 2004. The National Neurofibromatosis Foundation. 15 October 2004. Available URL: http://www.nf.org/ "NMF Home Page." 2004. The National Marfan Foundation. 15 October 2004. Available URL: http://www.marfan.org/nmf/index.jsp "Parent Project: Muscular Dystrophy: Leading the Duchenne Muscular Dystrophy Community." 12 October 2004. Parent Project Muscular Dystrophy. 15 October 2004. Available URL: http://www.parentprojectmd.org/news/latest/index.html "PKD Foundation: For Research in Polycyctic Kidney Disease." PKD Foundation. 15 October 2004. Available URL: http://www.pkdcure.org/home.htm "Prevention Through Genetic Testing." 10 October 2004. American Hemochromatosis Society. 15 October 2004. Available URL: http://www.americanhs.org/ "Welcome to the National Tay-Sachs & Allied Diseases Association, Inc. Web Site." NTSAD. 15 October 2004. Available URL: http://www.ntsad.org/ Images U.S. Department of Energy Office of Science. "Human Genome Project Information: Image Gallery." 11 March 2004. Internet. 23 September 2004. Available URL: http://www.ornl.gov/sci/techresources/Human_Genome/education/images.shtml Meisner, Gary. "Phi: The Golden Number: DNA." 2004. Internet. 23 September 2004. Available URL: http://www.goldennumber.net/dna.htm. Used with permission. AAA-Backgrounds. "Backgrounds." 2000. Internet. 2 October 2004. Available URL: http://www.aaa-backgrounds.com Back to Top Created by Pamela Aban -- September 27,
2004
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