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| Healing
The Soul in the Age of the Brain: Becoming Conscious in an Unconscious World
by Elio Frattaroli, M.D. The Value of Consciousness I wrote Healing the Soul in the Age of the Brain because I believe that our society is in a state of moral crisis. Our lives are so consumed by the dehumanizing forces of materialism that we have lost touch with the deeper needs and values of the soul. Culturally, we value physical appearances, material possessions, creature comforts, and addictive pleasures, as if we really believed that the one who dies with the most toys wins. We then rationalize the emptiness of these materialistic values by invoking another kind of materialism—that of modern science, which gives credence only to what can be seen and measured and believes that only the physical is real. Modern psychiatry typifies the shortsightedness of this scientific world view. Its theory that mental illness is a chemical imbalance and that all inner experience is a byproduct of brain activity—the so-called Medical Model—views human beings essentially as biological puppets, controlled by the strings of DNA and brain wiring, without free will or higher consciousness. Focusing exclusively on brain and behavior, it denies the spiritual element in human nature and treats the inner life of human beings — the essence of our humanity, the source of our joy, our anxiety, our despair, of our very culture itself, including our scientific theories – not only as if it didn’t matter, but as if it didn’t even exist. I believe that this materialistic way of thinking is hazardous to the health of our culture. It promotes the delusional expectation that we can eliminate suffering and achieve a state of contented normalcy simply by taking a pill. It subverts our ideals of moral responsibility by encouraging us to rationalize anything that disturbs us within ourselves as the accidental product of an abnormal brain state: My neurotransmitters made me do it. Such dehumanizing beliefs reinforce a dehumanizing impulse that is already present within human nature. Like Dickens’s Scrooge and Disney’s Pinocchio, we are all tempted to ignore the inner voice of the soul in our pursuit of external tokens of happiness—not only because we are seduced by our culture’s materialistic values but because we are driven from within by our own materialistic passions and by our addictive need for quick, painless fixes for anything disturbing in our lives. The result is a kind of cultural mental illness in which we are, in effect, driven to dehumanize ourselves—to lose ourselves in materialistic illusions—in order to evade the fundamental anxiety of the human condition. To cure this illness requires an inner process of re-humanization—of our values, our science, and most importantly, our way of understanding our own experience. Like Scrooge and Pinocchio, we need to wake up from our shallow materialistic illusions and reclaim what we know in our heart of hearts to be true. We need to turn inward, to listen to the inner voice of our authentic self. And we need a science that acknowledges the existence of this inner self; that recognizes human consciousness not as an electrochemical process in the brain but as an irreducible experience of the soul. In my book, I propose a new model of psychiatry and of human nature based on just such a science. This Psychotherapeutic Model understands mental illness not only in neurological but also in personal terms, as an inner emotional conflict —a disharmony of body, brain, mind and spirit—that is intrinsic to the human condition. Psychologically, inner conflict involves a disturbing unconscious emotion, threatening to become conscious, that triggers anxiety, shame, or guilt, and can lead to the development of a symptom. Conflict is resolved and the symptom disappears when we can consciously feel and accept as part of ourselves the unsettling emotion that is generating the symptom. Although medication can be useful in relieving symptoms, it is important to remember that the symptom is actually part of the healing process. Since the time of Hippocrates, physicians have understood symptoms as a manifestation of the “healing power of nature,” the organism’s adaptive response to disease. Just as symptoms like fever and cough are not diseases but rather the body’s attempt to fight an infection, so too psychiatric symptoms like anxiety and depression are not themselves diseases but rather the soul's attempt to resolve an inner conflict —by forcing us to pay attention to the unconscious dark side of ourselves that we would rather ignore. This understanding reclaims the true meaning of psychiatry: healing the soul. It views the anxiety and the disturbing symptoms of mental illness not merely as a chemical imbalance in the brain (though that may be part of it) but more importantly as a wake-up call for the soul. Healing—making whole the divided self—comes through experiencing, accepting, and taking responsibility for the dark side of ourselves in what I describe as the six phases of the psychotherapeutic process: an inward journey of self-discovery in which we allow ourselves to feel what we really feel and so become who we truly are. |
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| More
talk, fewer pills, says local psychiatrist By Stacey Burling Inquirer Staff Writer Posted on Mon, Jun. 03, 2002 |
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| Depression,
says psychiatrist and psychoanalyst Elio Frattaroli, can be a good thing.
So can anxiety, and even psychosis. Like physical pain, these symptoms are signs that something is amiss inside. But, if approached correctly, they also present an opportunity for emotional growth. Making people better is not just about making that pain go away with a pill, says Frattaroli, who is in private practice in Bala Cynwyd. It's about facing inner conflicts that caused emotional pain and talking about them in a way largely out of fashion in modern psychiatry. "The symptoms of mental illness," he said in a recent speech at the American Psychiatric Association meeting here, "can serve as a wake-up call, forcing us to pay attention to the deeper needs of the soul." Frattaroli thinks those deeper emotional needs are getting short shrift these days as most of his colleagues have embraced what he calls the "medical model" of mental illness, the view that psychiatric problems stem from chemical imbalances in the brain and therefore can be treated with chemicals. It took him eight years and 434 pages to make the point in his book, Healing the Soul in the Age of the Brain, which had the unfortunate release date of Sept. 10. The paperback will debut in August with a new subtitle: Why Medication Isn't Enough. Frattaroli, who gives medicines to about half his patients, thinks drugs should be used, not to stop psychic pain, but to dull it so that people can cope with their feelings and more clearly see their problems. Patients, he said, "deserve to be listened to and to be taken seriously. Having a 15-minute appointment, being given a pill and told to come back in a month for another 15-minute appointment, isn't adequate treatment." While some psychiatrists say they do little long-term psychotherapy because insurance companies won't pay for it, Frattaroli contends psychiatrists developed this biological view of mental illness, giving insurance companies the rationale to cut back on talk therapy. And, he said, many psychiatrists no longer believe in psychotherapy. "Psychiatrists don't spend a lot of time listening to patients anymore because they don't think they need to," he said. In his view, people may be biologically predisposed to depression or mania or psychosis, but their symptoms are not merely the result of brain structure. Even schizophrenics, he said, are more likely to hear voices when under stress. And, while many people describe depression as a feeling that descends on them for no reason, he thinks that's never the case. "Depression is always about something," Frattaroli said. "Anxiety is always about something. It's true that it often doesn't feel that way." The biological approach gives people an easy out. It "allows us to see anything we don't like about ourselves as a chemical imbalance," he said. "We don't have to take personal responsibility for things we don't like." In the early '90s, Frattaroli, now 54, had a panic attack while giving a speech. He had heart palpitations. He felt lightheaded. His voice shook. Afterward, he was terrified it would happen again. Through analysis, he says, he realized that he had been conflicted about the speech. He was feeling competitive and had a "hostile impulse to show up" a good friend. Years later, though, he still takes anti-anxiety medicine before speeches. The therapy, he said, "changed my whole way of approaching that task, but it didn't completely take away the memory of what happened and the awareness that my neurophysiology was capable of producing that reaction." The experience has made him more sympathetic to his patients and appreciative of psychiatric medication. Frattaroli thinks science would like to explain all of our thoughts and feelings, our sense of self, with chemical and electrical reactions in the brain. He believes that's impossible. "I think there are certain things that will never be able to be seen, touched or measured," said Frattaroli, a lapsed Catholic who believes in a "healing force" in nature and humanity. "There's more to our inner experience than can ever be explained with brain chemistry." He described the soul metaphorically as "the place where experiencing happens... the inner place where we feel our emotions and also the place where we feel connecting to other people." Frattaroli, who studied Shakespeare at Harvard before going into psychiatry, uses Hamlet to illustrate his ideas. For 400 years, he said in his speech, millions have understood Hamlet's depression "as an emotional crisis in his quest for truth, love, and moral integrity; an expression of his noble struggle with the slings and arrows of outrageous fortune - i.e., a corrupt and dysfunctional family and society - and with an impossible combination of inner stresses: grief, righteous outrage, malicious vengefulness, unrequited love, disturbing sexual passion and existential anxiety. "Even modern psychiatrists tend to think about Hamlet that way when we aren't wearing our psychiatric hats. But just let a patient like Hamlet come into our office and fill out a Beck's depression inventory, and suddenly his problem will be reduced to a chemical imbalance. That's how superficial and dehumanizing - how weary, stale, flat and unprofitable - our current psychiatric thinking has become." Frattaroli has no illusions that his book will sell most Americans, or their insurance companies, on the kind of therapy he practices. "I'm trying to sell the importance of paying attention to what you're feeling," he said. "I think that's a message everybody is capable of hearing." |
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| Perspectives
- Vol. 1, No. 2 Towards An Epigenetic Biology And Medicine Richard C. Strohman, Professor Emeritus Molecular and Cell Biology University of California, Berkeley |
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| Modern
biomedical science has replaced the concept of "organism" with the that
of a survival machine in which life is reduced to the mechanistic workings
of an evolved collection of genes. Our research establishment is mistakenly
dedicated to recreating genomes to reflect a continuously degraded world.
But genomes are actually adaptive and conserved entities and are highly interactive internally and with the world. They are difficult to change and their complexity does not permit linear genetic prediction of health. or diagnosis of disease. The logic of health and disease resides not in genes alone, but in holistic, epigenetic regulatory networks in cells and in all organisms - networks that are coextensive with the external world and which require for a manifestation of wellness the presence of environments reflective of our inherited and conserved genetic and epigenetic capacities. Developments in the life sciences make it clear that the current genetic paradigm is too limited by mechanistic and deterministic models to accommodate new perceptions of the organism! Despite the successes of the currently accepted genetic paradigm in biomedical science, and the continuing pursuit of applied research using its models, basic research has revealed conflicts and inadequacies inherent in the assumptions supporting the paradigm [1]. What emerges from these challenges to concepts of genetic causality is the beginning of a new biological paradigm, an epigenetic view that embraces creative characteristics, fusion of genetic with environmental signals [2] and other aspects beyond currently accepted biomedical theory. Epigenetic Biology Defined The term epigenetic has been used in the past to describe organismal development as a nonlinear, complex process Usually it was used to distinguish developmental complexity from the theory of 'preformation' which claimed that the becoming of complex organisms was simply a matter of growth of tiny preformed bodies In modern form preformation is recreated in terms of DNA and genetic programs within which developmental instructions reside. Of course, this version of preformation based on DNA as the transcendent aspect of information is also wrong. The new biological paradigm has an epigenetic basis. Characterized by enormous complexity and by phenotypic (behavior) possibility of great variability, biological systems actually occupy many fewer phenotypic states than are possible. Choice is then a scientific rather than a metaphysical concept observable at all levels of biological organization [3]. Because functional states evolved by biological entities (cells, organisms) are adaptive, creative choice also comes into a scientific focus. 'Choice' is no longer an anthropomorphic artifact, but an observable phenomenon. Organisms display enormous fidelity in their developmental and growth patterns. Memory, therefore, is an important characteristic of living things. Biological memory, however, differs from memory in physical systems (computers, other machines) because it does not reside in fixed predictable locations. Instead, it is distributed throughout dynamical system which themselves show enormous informational redundancy. Holistic memory must, therefore, be a primary characteristic of living systems. Four major features of living systems, down to the cellular level, are a. creative choice, b. dynamical information storage or holist) memory, c. non-linear or determinative chaos, and d. informational redundancy. These features are not currently addressed by the prevailing biomedical paradigm and consequent!, offer an opportunity to develop a new paradigm. The epigenetic features of life described here were formulated by the physicist, Walter Elsasser [3]. These features do not presently move beyond axioms or simple observables present in all life forms. They do not represent mechanisms but rather new starting points for thinking about relations between form and function. Since these features are not approached by the present governing paradigm of biology, they also provide a new opportunity at the level of biological epistemology and make insistent the need for biological theory that goes beyond reductionism. What is helpful in developing new approaches to biological systems is to make clear where our present thinking is, or might be inadequate; this analysis follows below. Points of Departure between Biomedical Reductionism and Emerging Epigenetic Biology Currently, biomedical sciences focus on what is predicted to be useful. Much work is in concert with ongoing basic research into fundamental aspects of cellular and molecular biology. For example, analysis of simple diseases with single gene causality is expected to produce new drugs based on molecular biology of cellular structures, receptors, and other molecules that mediate cellular function. However, this research bound by the reductionist model will not address the major human diseases. Because of the enormous complexity found in the simplest biological system and the inability of reductionism in general and determinism in particular to lead to new insights into these complex systems, the current paradigm fails in the areas shown in Table 1. These areas are discussed in the following paragraphs. Table 1. Areas confounding genetic determinism in biomedicine. AREA CONFOUNDING ELEMENTS Population Biology Complex traits not accessible to linear genetic analysis. Disease Natural History Most common diseases are not genetic. Evolutionary Biology No relationship between genetic and morphological complexity. Developmental Biology There are no genetic programs. Molecular and Cell Biology Informational redundancy confounds linear genetics. Population biology conflicts with genetic determinism Genetic determinism in current biomedical technology is based on the general equation of uniqueness between genes and phenotype: Unique Genes --Unique Effects (unique phenotypes). Under this equation we may assemble the major assumptions of biomedicine as follows: Genes determine diseases. Genes determine aging. Genetic analysis provides diagnosis and therapy for disease and aging. These assumptions underlie the human genome project, the multi-billion dollar national project to sequence, clone, and map the 100,000 genes in the 23 pairs of human chromosomes. But fundamental rules governing population genetics stand in at least partial opposition to the uniqueness equation and to the assumptions. Essentially, the unique relationship between genes and phenotypes is flawed because most complex phenotypes (including diseases) have a unique genetic basis. Rather the relationship between genome and phenome is characterized by great complexity involving interaction between many genes, gene products and environmental signaling. This interaction may involve 10, 100, 1,000 or more genes for any common disease like cancer or the heart diseases [4] In addition, the interaction will be function of personal natural history and present environmental setting, so that even in simplified cases, where genetic connections may be traced, the genes will have different effects in different environments. Population genetics shows that a precipitating environment is required to produce disease manifestation across the entire range of genetic variation [4,5]. For cardiovascular disease, most cancers, non-insulin-dependent diabetes, and most mental diseases, there is no evidence for single-gene causality -- and certainly none that would support the uniqueness equation. Disease natural history conflicts with genetic determinism. Diseases determined at fertilization, as Thomas McKeown [5] has made clear, are based in genetic abnormalities of one kind or another. Examples are sickle cell anemia, cystic fibrosis, and Duchenne muscular dystrophy. There are literally thousands of these diseases, but they occur within the human population at extremely low frequency and account for less than 2 per cent of our total disease load. So, only 2 per cent of the time does the 'bad gene causes disease' mechanism operate, while 98 per cent of the time humans are born with genetic constitutions capable of supporting a life span of over 100 years, an average life expectancy of about 85 years, and an old age relatively free of morbidity [5] The human genome needs to find itself in an environment for which it has adequate representation - proper nutrition, housing, and sanitation, to name the obvious requirements - but the deterministic/mechanistic model of sabotage from within is not adequate to explain most human diseases. Evolutionary Biology Conflicts with Genetic Determinism Most people, scientists included, are not aware of problems within evolutionary biology having to do with genetic mechanisms. These problems do not provide any weakening of the foundations supporting evolution; they do provide concern that we may have oversimplified the idea that evolution is to be explained by genetic mechanisms alone. Again, this is a complex area but we can state the following. In the area of evolution, genetic change is seen as one end point of evolution, and change in genes (mutations) is seen as one element providing a basis for phenotypic variance that may be acted upon by natural selection. But gene changes alone will not and cannot explain evolution. The mechanistic genetic model does not explain how individual organisms generate their phenotypes in the presence (or absence) of gene changes in a variety of environmental settings [6]. Individual development is one missing link in our current theory of evolution, a link that is recognized, and one that the biological community is now struggling to mend and incorporate into a more complete picture of natural selection. As an illustration, there is the absence of relationship between genetic and morphological complexity of species. Some closely related species cannot be seen by expert examination to be different (have different morphology), yet they show great variation in complexity at both genetic and protein sequence levels. Somehow organisms are able to take vastly different genomes and construct nearly identical phenomes. This cannot be explained by a simple linear genetic paradigm. Equally puzzling, humans and chimps have a very different morphology, yet humans do not differ genetically from chimps by more than one to two per cent Somehow we are able to construct very different organisms from very similar genomes; this IS currently not explained by genetic theory. Developmental Cell and Molecular Biology Conflict with Genetic Determinism First, genetic determinism for complex traits has assumed the notion of 'gene programs' to help explain the causal linkage between genes and phenotype. But this assumption has been found to be without experimental verification. There are no genetic programs [7]. There are only genes that encode for proteins. Some of these genes, and their protein products, are extremely important. When they are mutated or missing, the effects on a complex trait are profound. We have assumed that these genes control this or that trait, but now we see that these genes only supply an important protein used by the cell or organism in constructing a complex trait. Genes, for example, do not control developmental traits; they only contain information necessary for the synthesis of proteins used in development -- in the assembly of the organism. The control for this assembly is not found in the DNA; it is elsewhere within the cell and it depends on a vast array of information coming from many sectors of the organism. This control corresponds to epigenetic regulation. Far from being controlled by simple, linear genetic causality, development is seen to rely on a complex, nonlinear determinism closer perhaps to chaos theory than it is to genetic theory. It is, of course, an amalgam of both. Creativity is evident, a creativity at the cellular level that uses genetic and other information to construct the organism. This creativity is hidden in the epigenetic regulatory processes of living cells; a creativity that may be illuminated by a new biological paradigm capable of going beyond and encompassing the genetic paradigm. Second, informational redundancy in organisms, and especially within cells, confounds the uniqueness equation because more than one gene can bring about the same. The uniqueness equation completely fails, as there is informational redundancy not only at the gene level, but at the epigenetic level as well. There are many examples in the current literature of experimental biology testifying to the ability of the organism to get along without what were thought to be crucial genes [1]. The organism, when a gene is missing, finds other genes or finds new ways (epigenetic controls) to use vast numbers of remaining genes to produce the same or highly similar phenotypes [1]. Conclusion The new biology is discovering important areas of conflict with the prevailing paradigm of genetic determinism. These discoveries lead us into new realms of complexity, and we see that obvious characteristics of life such as purpose, and creative (as distinct from vital) forces need to be accommodated. An epigenetic paradigm holds possibilities for recapturing these characteristics within a scientific framework. Through epigenetic controls or vast networks of genes, gene products, and environmental signals found in living cells there is an opportunity for a new understanding. This understanding may augment the idea of body wisdom. Rather than the need to orient ourselves to a technology devoted to engineering genes so we can fit imperfectly into a persistently degraded world, we may come to understand how to re-engineer the world to reflect the ancient and highly adapted genome that we humans bring with us as our evolved informational capacity The genome is well, changes only slowly and with difficulty; the environment is not well and can be changed to reflect human needs inseparable from the diverse needs of the planet itself. An epigenetic paradigm, then, is a goal worthy of our highest priority and one toward which we have taken the first steps. References 1. STROHMAN, R.C. Ancient Genes, Wise Bodies, Unhealthy People: Limits of Genetic Thinking in Biology and Medicine'. (1993). Perspectives in Biology and Medicine, 37 (I), pp.112-144. 2. WOLF, S. & BRUHN, J. G. (1992) The Power of Clan. New Jersey: Transactional Publishers. 3. ELSASSER, W. (1987) Reflections on the Theory of Organisms. Quebec: Orbis Publishing. 4. Wahlsten, D. (1990) 'Insensitivity of the analysis of variance to heredity-environment interaction'. Behav. and Brain Sci.13 109-161. 5. McKEOWN, I. (1988). The Origins of Human Disease. New York: Basil Blackwell, Inc. 6. Gottlieb, G. (1992). Individual Development and Evolution: The Genesis of Novel Behaviour. Oxford: Oxford University Press. 7. NIJHOUT H. F (1990) 'Metaphors and the Role of Genes in Development'. BioEssays 12 441 446. 8. NEEL, J.V. (1961) a Geneticist looks at Modern Medicine. Harvey Lecture Series. pp. 127-150. New York: Academic Press. This article originally appeared in Network and is republished here with permission. Reference Strohman, Richard C. (1996). Toward an epigenetic biology & medicine. [Online]. Network. [1996, May 15]. Perspectives |
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| Human Complexity Betrayed by Medical Model | ||||||||||||||||||||||
| Keynote
Address:Executive Summary Leadership for Innovation in Health Care June 2000 Cambridge, MA Sponsors: Innovations in American Government Program, The Ford Foundation John F. Kennedy School of Government Bureau of Primary Health Care, US Department of Health and Human Services The Access Project, Robert Wood Johnson | ||||||||||||||||||||||